Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
Multifaceted role of the placental growth factor (PlGF) in the antitumor immune response and cancer progression
L Albonici, MG Giganti, A Modesti, V Manzari… - International Journal of …, 2019 - mdpi.com
The sharing of molecules function that affects both tumor growth and neoangiogenesis with
cells of the immune system creates a mutual interplay that impairs the host's immune …
cells of the immune system creates a mutual interplay that impairs the host's immune …
The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases
T Van Bergen, I Etienne, F Cunningham… - Progress in retinal and …, 2019 - Elsevier
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF)
family. Upon binding to VEGF-and neuropilin-receptor sub-types, PlGF modulates a range of …
family. Upon binding to VEGF-and neuropilin-receptor sub-types, PlGF modulates a range of …
Systems biology of angiogenesis signaling: Computational models and omics
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …
cellular signal transduction, activation, proliferation, differentiation, as well as their …
[PDF][PDF] Injured axons instruct Schwann cells to build constricting actin spheres to accelerate axonal disintegration
After a peripheral nerve lesion, distal ends of injured axons disintegrate into small fragments
that are subsequently cleared by Schwann cells and later by macrophages. Axonal debris …
that are subsequently cleared by Schwann cells and later by macrophages. Axonal debris …
VEGF-a stimulus for neuronal development and regeneration in the CNS and PNS
V Theis, C Theiss - Current Protein and Peptide Science, 2018 - ingentaconnect.com
The vascular endothelial growth factor (VEGF) is a homodimeric disulfide bound
glycoprotein that promotes endothelial growth, accompanied by higher vascular …
glycoprotein that promotes endothelial growth, accompanied by higher vascular …
VEGF/VEGFR axis and its signaling in melanoma: Current knowledge toward therapeutic targeting agents and future perspectives
Melanoma is responsible for most skin cancer-associated deaths globally. The progression
of melanoma is influenced by a number of pathogenic processes. Understanding the …
of melanoma is influenced by a number of pathogenic processes. Understanding the …
[PDF][PDF] Real-time ligand binding of fluorescent VEGF-A isoforms that discriminate between VEGFR2 and NRP1 in living cells
Fluorescent VEGF-A isoforms have been evaluated for their ability to discriminate between
VEGFR2 and NRP1 in real-time ligand binding studies in live cells using BRET. To enable …
VEGFR2 and NRP1 in real-time ligand binding studies in live cells using BRET. To enable …
Neuroprotective effects of VEGF in the enteric nervous system
I Hecking, LN Stegemann, V Theis, M Vorgerd… - International Journal of …, 2022 - mdpi.com
Although the enteric nervous system (ENS) functions largely autonomously as part of the
peripheral nervous system (PNS), it is connected to the central nervous system (CNS) via …
peripheral nervous system (PNS), it is connected to the central nervous system (CNS) via …
Multi-physics interactions drive VEGFR2 relocation on endothelial cells
Abstract Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) is a pro-angiogenic
receptor, expressed on endothelial cells (ECs). Although biochemical pathways that follow …
receptor, expressed on endothelial cells (ECs). Although biochemical pathways that follow …