Reactive nitrogen species (RNS) are formed when there is an abnormal increase in the level
of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) and/or by the …

Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …

The sympathetic and parasympathetic nervous systems regulate the activities of internal
organs, but the molecular and functional diversity of their constituent neurons and circuits …

KarXT combines xanomeline, an M1/M4 preferring muscarinic agonist with no direct D2
receptor antagonism, with the peripherally restricted anticholinergic trospium. In …

Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …

Importance and objectives There is unmet medical need to understand the pathogenic
mechanism of the panoply of clinical manifestations associated with silicone breast implants …

Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic
receptors in the molecular pathology of schizophrenia. From these data it was proposed that …

G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …

Targeting allosteric sites of M1 muscarinic acetylcholine receptors (M1 receptors) is a
promising strategy to treat neurocognitive disorders, such as Alzheimer's disease and …

Cancers arising from gastrointestinal epithelial cells are common, aggressive, and difficult to
treat. Progress in this area resulted from recognizing that the biological behavior of these …