An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases

DM Teleanu, AG Niculescu, II Lungu, CI Radu… - International journal of …, 2022 - mdpi.com
Oxidative stress has been linked with a variety of diseases, being involved in the debut
and/or progress of several neurodegenerative disorders. This review intends to summarize …

Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases

P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

RONS and oxidative stress: An overview of basic concepts

AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Reactive oxygen species: drivers of physiological and pathological processes

J Checa, JM Aran - Journal of Inflammation research, 2020 - Taylor & Francis
Abstract Since the Great Oxidation Event, about 2.4 billion years ago, the Earth is immersed
in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a …

Superoxide dismutase administration: A review of proposed human uses

AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …

Superoxide dismutase: an updated review on its health benefits and industrial applications

MN Islam, A Rauf, FI Fahad, TB Emran… - Critical Reviews in …, 2022 - Taylor & Francis
Many short-lived and highly reactive oxygen species, such as superoxide anion (O2-) and
hydrogen peroxide (H2O2), are toxic or can create oxidative stress in cells, a response …

Overview of the antioxidant and anti-inflammatory activities of selected plant compounds and their metal ions complexes

P Mucha, A Skoczyńska, M Małecka, P Hikisz… - Molecules, 2021 - mdpi.com
Numerous plant compounds and their metal-ion complexes exert antioxidative, anti-
inflammatory, anticancer, and other beneficial effects. This review highlights the different …

Nanozymes based on metal-organic frameworks: Construction and prospects

F Wang, L Chen, D Liu, W Ma, P Dramou… - TrAC Trends in Analytical …, 2020 - Elsevier
Nanozymes, the nanomaterials with catalytic function similar to natural enzymes, are well-
known for their distinct merits such as low cost and high stability. Among them, metal-organic …

Computational scoring and experimental evaluation of enzymes generated by neural networks

SR Johnson, X Fu, S Viknander, C Goldin… - Nature …, 2024 - nature.com
In recent years, generative protein sequence models have been developed to sample novel
sequences. However, predicting whether generated proteins will fold and function remains …

Chlorogenic acid attenuates dextran sodium sulfate‐induced ulcerative colitis in mice through MAPK/ERK/JNK pathway

W Gao, C Wang, L Yu, T Sheng, Z Wu… - BioMed Research …, 2019 - Wiley Online Library
Objective. Observe the protective effect of chlorogenic acid on dextran sulfate‐induced
ulcerative colitis in mice and explore the regulation of MAPK/ERK/JNK signaling pathway …