Research in environmental toxicology involving pharmaceuticals and personal care
products (PPCPs) has increased greatly over the last 10–15 years. Much research has been …

Fish sex ratio (SR) is an endpoint potentially indicating both endocrine activity and adversity,
essential elements for identifying Endocrine Disrupting Chemicals (EDCs) as required by …

Vitellogenin (VTG), a biomarker for endocrine activity, is a mechanistic component of the
regulatory assessment of potential endocrine-disrupting properties of chemicals. This review …

Plasticizers are broadly classified as phthalate or nonphthalate. Recently, acetyl tributyl
citrate (ATBC), an environmentally friendly nonphthalate plasticizer, was revealed to have …

Chemical induced changes in fish biomarkers vitellogenin (VTG), secondary sex
characteristics (SSC), and sex ratio indicate modes/mechanisms of action (MOAs) of EAS …

The medaka extended one‐generation test (MEOGRT) was developed as a
multigenerational toxicity test for chemicals, particularly endocrine‐disrupting chemicals …

Nonylphenol (NP) is a toxic xenobiotic compound, which is persistent in the aquatic
environment and is extremely toxic to aquatic organisms. Although the exact molecular …

Estrone (E1) is one of the predominant natural estrogens detected in aquatic environments,
yet little is known about its effects on the endocrine system in fish. In this study, the sex ratio …

Abstract Effects observed within one generation disregard potential detrimental effects that
may appear across generations. Previously we have developed a two generation Daphnia …

Testis-ova differentiation in sexually mature male medaka (Oryzias latipes) is easily induced
by estrogenic chemicals, indicating that spermatogonia persist in sexual bipotentiality, even …