Epigenetics and environment: a complex relationship
O Aguilera, AF Fernández, A Muñoz… - Journal of applied …, 2010 - journals.physiology.org
The epigenomes of higher organisms constantly change over time. Many of these epigenetic
changes are necessary to direct normal cellular development and differentiation in the …
changes are necessary to direct normal cellular development and differentiation in the …
[HTML][HTML] Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
I Grammatikakis, AC Panda, K Abdelmohsen… - Aging (Albany …, 2014 - ncbi.nlm.nih.gov
During aging, progressive deleterious changes increase the risk of disease and death.
Prominent molecular hallmarks of aging are genomic instability, telomere attrition …
Prominent molecular hallmarks of aging are genomic instability, telomere attrition …
The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome
Introduction Mammalian genomes encode thousands of large noncoding RNAs (lncRNAs),
many of which regulate gene expression, interact with chromatin regulatory complexes, and …
many of which regulate gene expression, interact with chromatin regulatory complexes, and …
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
KL Yap, S Li, AM Muñoz-Cabello, S Raguz, L Zeng… - Molecular cell, 2010 - cell.com
Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell
growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the …
growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the …
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation
Recent investigations have implicated long antisense noncoding RNAs in the epigenetic
regulation of chromosomal domains. Here we show that Kcnq1ot1 is an RNA polymerase II …
regulation of chromosomal domains. Here we show that Kcnq1ot1 is an RNA polymerase II …
Long noncoding RNA in genome regulation: prospects and mechanisms
T Hung, HY Chang - RNA biology, 2010 - Taylor & Francis
Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the
epigenome [1, 2]. These long, polyadenylated RNAs do not code for proteins, but function …
epigenome [1, 2]. These long, polyadenylated RNAs do not code for proteins, but function …
The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin
A number of large noncoding RNAs (ncRNAs) epigenetically silence genes through
unknown mechanisms. The Air ncRNA is imprinted—monoallelically expressed from the …
unknown mechanisms. The Air ncRNA is imprinted—monoallelically expressed from the …
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre
RNA, including long noncoding RNA (lncRNA), is known to be an abundant and important
structural component of the nuclear matrix. However, the molecular identities, functional …
structural component of the nuclear matrix. However, the molecular identities, functional …
Multigenerational epigenetic adaptation of the hepatic wound-healing response
M Zeybel, T Hardy, YK Wong, JC Mathers, CR Fox… - Nature medicine, 2012 - nature.com
We investigated whether ancestral liver damage leads to heritable reprogramming of
hepatic wound healing in male rats. We found that a history of liver damage corresponds …
hepatic wound healing in male rats. We found that a history of liver damage corresponds …
[HTML][HTML] Long non-coding RNA HOTAIR is associated with human cervical cancer progression
HJ Kim, DW Lee, GW Yim, EJ Nam… - International …, 2015 - spandidos-publications.com
The functions of many long non-coding RNAs (lncRNAs) in human cancers remain to be
clarified. The lncRNA Hox transcript antisense intergenic RNA (HOTAIR) has been reported …
clarified. The lncRNA Hox transcript antisense intergenic RNA (HOTAIR) has been reported …