Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Cardiovascular disease is the leading cause of death, medical complications, and
healthcare costs. Although recent advances have been in treating cardiovascular disorders …

Background: Doxorubicin is a widely used and effective chemotherapy, but the major limiting
side effect is cardiomyopathy which in some patients leads to congestive heart failure …

Daunorubicin (DNR-) induced cardiotoxicity seriously restricts its clinical application.
Transient receptor potential cation channel subfamily C member 6 (TRPC6) is involved in …

The canonical transient receptor potential 6 gene, TRPC6, has been implicated as a putative
risk gene for chemotherapy-induced congestive heart failure, but knowledge of specific risk …

Anthracyclines are one of the most widely used and effective chemotherapies in oncology,
but their most important side effect is the cumulative, dose-related cardiotoxicity leading to …

Baseline cardiovascular assessment before the initiation of potentially cardiotoxic cancer
therapies is a key component of cardio-oncology, aiming to reduce cardiovascular …

Due to longer lifespans in societies in industrialized countries, cardiovascular diseases are
becoming increasingly important for medical research. It has already been shown that the …

Background The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer
agents are well known, but molecular genetic testing is lacking for the early identification of …

Introduction: Emerging evidence suggests that Chemotherapy (CT) treated breast cancer
survivors (BCS) who have “risk variants” in genes may be more susceptible to cognitive …