Macrophages and neutrophils play a decisive role in host responses to intracellular bacteria
including the agent of tuberculosis (TB), M ycobacterium tuberculosis as they represent the …

Significance: Fluorescent protein sensors have revitalized the field of redox biology by
revolutionizing the study of redox processes in living cells and organisms. Recent Advances …

Recent research on plant responses to bacterial attack has identified extracellular and
intracellular host receptors that recognize conserved pathogen-associated molecular …

Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …

Abstract The Mycobacterium tuberculosis (Mtb) DosRST two-component regulatory system
promotes the survival of Mtb during non-replicating persistence (NRP). NRP bacteria help …

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

The remarkable ability of Mycobacterium tuberculosis to survive attacks from the host
immune response and drug treatment is due to the resilience of a few bacilli rather than a …

The continued rise of antibiotic-resistant bacterial infections has motivated alternative
strategies for target discovery and treatment of infections. Antivirulence therapies function …

The capacity of Mycobacterium tuberculosis (Mtb) to tolerate multiple antibiotics represents a
major problem in tuberculosis (TB) management. Heterogeneity in Mtb populations is one of …

Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the
course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often …