Translation inhibition and stress granules in the antiviral immune response
C McCormick, DA Khaperskyy - Nature Reviews Immunology, 2017 - nature.com
Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …
rapidly reprioritize the translation machinery in response to varied environmental assaults …
The eIF2α kinases: their structures and functions
Cell signaling in response to an array of diverse stress stimuli converges on the
phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of …
phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of …
Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
Neuronal inclusions of aggregated RNA‐binding protein fused in sarcoma (FUS) are
hallmarks of ALS and frontotemporal dementia subtypes. Intriguingly, FUS's nearly …
hallmarks of ALS and frontotemporal dementia subtypes. Intriguingly, FUS's nearly …
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death
Summary Expanded GGGGCC (G4C2) nucleotide repeats within the C9ORF72 gene are the
most common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and …
most common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and …
RNA mimics of green fluorescent protein
JS Paige, KY Wu, SR Jaffrey - Science, 2011 - science.org
Green fluorescent protein (GFP) and its derivatives have transformed the use and analysis of
proteins for diverse applications. Like proteins, RNA has complex roles in cellular function …
proteins for diverse applications. Like proteins, RNA has complex roles in cellular function …
Altered ribostasis: RNA-protein granules in degenerative disorders
The molecular processes that contribute to degenerative diseases are not well understood.
Recent observations suggest that some degenerative diseases are promoted by the …
Recent observations suggest that some degenerative diseases are promoted by the …
[HTML][HTML] Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease
H Mahboubi, U Stochaj - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Stress granule (SG) assembly is a conserved cellular strategy to minimize stress-related
damage and promote cell survival. Beyond their fundamental role in the stress response …
damage and promote cell survival. Beyond their fundamental role in the stress response …
mRNP granules: assembly, function, and connections with disease
JR Buchan - RNA biology, 2014 - Taylor & Francis
Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …
ALBA proteins confer thermotolerance through stabilizing HSF messenger RNAs in cytoplasmic granules
High temperature is one of the major environmental stresses affecting plant growth and
fitness. Heat stress transcription factors (HSFs) play critical roles in regulating the expression …
fitness. Heat stress transcription factors (HSFs) play critical roles in regulating the expression …
SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production
A key to tackling the coronavirus disease 2019 (COVID-19) pandemic is to understand how
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manages to outsmart host …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manages to outsmart host …