Adipose tissue performs complex metabolic and endocrine functions. Among the endocrine
products produced by adipose tissue are tumour necrosis factor α, interleukin 6, acylation …

The prevalence of obesity is on the rise. What was once considered a simple disease of
energy imbalance is now recognized as a complex condition perpetuated by neuro-and …

Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed
descendants. This transgenerational inheritance has significant implications for …

Leptin, the product of the ob gene, regulates food intake, energy expenditure, and other
physiological functions of the peripheral tissues. Leptin receptors have been identified in the …

Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative
stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and …

The breadth of genetic and phenotypic variation among inbred strains is often
underappreciated because assessments include only a limited number of strains. Evaluation …

We examined the preventive effect of Momordica charantia L. fruit (bitter melon) on
hyperglycemia and insulin resistance in C57BL/6J mice fed with a high-fat (HF) diet. Firstly …

Several lines of evidence support protective as well as deleterious effects of oleic acid (OA)
on Alzheimer's disease (AD) and other neurological disorders; however, the bases of these …

In the present study we developed a model of diet-induced obesity (DIO) in male C57 BL/6J
mice using an 8-wk high fat diet. This model should better reflect the physiology of the …

IGF-I is important for postnatal body growth and exhibits insulin-like effects on carbohydrate
metabolism. The function of liver-derived IGF-I is still not established, although we previously …