Metastatic colorectal cancer: mechanisms and emerging therapeutics
AE Shin, FG Giancotti, AK Rustgi - Trends in pharmacological sciences, 2023 - cell.com
Metastatic colorectal cancer (mCRC) remains a lethal disease with an approximately 14% 5-
year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with …
year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with …
Immunosurveillance in clinical cancer management
The progression of cancer involves a critical step in which malignant cells escape from
control by the immune system. Antineoplastic agents are particularly efficient when they …
control by the immune system. Antineoplastic agents are particularly efficient when they …
Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment
A single biomarker is not adequate to identify patients with gastric cancer (GC) who have the
potential to benefit from anti-PD-1/PD-L1 therapy, presumably owing to the complexity of the …
potential to benefit from anti-PD-1/PD-L1 therapy, presumably owing to the complexity of the …
Therapeutic landscape and future direction of metastatic colorectal cancer
H Bando, A Ohtsu, T Yoshino - Nature Reviews Gastroenterology & …, 2023 - nature.com
In the era of targeted therapy based on genomic alterations, the treatment strategy for
metastatic colorectal cancer (mCRC) has been changing. Before systemic treatment …
metastatic colorectal cancer (mCRC) has been changing. Before systemic treatment …
The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers
Q Tang, Y Chen, X Li, S Long, Y Shi, Y Yu… - Frontiers in …, 2022 - frontiersin.org
Programmed cell death protein-1 (PD-1) is a checkpoint receptor expressed on the surface
of various immune cells. PD-L1, the natural receptor for PD-1, is mainly expressed in tumor …
of various immune cells. PD-L1, the natural receptor for PD-1, is mainly expressed in tumor …
Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti-PD1/PD-L1 immunotherapy in non …
F Ghiringhelli, F Bibeau, L Greillier, JD Fumet, A Ilie… - …, 2023 - thelancet.com
Summary Background Anti-PD-1 and PD-L1 antibodies (mAbs) are approved
immunotherapy agents to treat metastatic non-small cell lung cancer (NSCLC) patients. Only …
immunotherapy agents to treat metastatic non-small cell lung cancer (NSCLC) patients. Only …
Immune checkpoint inhibitors combined with targeted therapy: the recent advances and future potentials
B Li, J Jin, D Guo, Z Tao, X Hu - Cancers, 2023 - mdpi.com
Simple Summary Immune checkpoint inhibitors (ICIs) are the most mature treatment of
immunotherapy and have changed the mode of cancer treatment. Recent studies showed …
immunotherapy and have changed the mode of cancer treatment. Recent studies showed …
Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy
Y Xi, L Chen, J Tang, B Yu, W Shen… - Immunological …, 2024 - Wiley Online Library
Immunogenic cell death (ICD) is a unique mode of cell death, which can release
immunogenic damage‐associated molecular patterns (DAMPs) and tumor‐associated …
immunogenic damage‐associated molecular patterns (DAMPs) and tumor‐associated …
[HTML][HTML] Systemic treatment for metastatic colorectal cancer
W Leowattana, P Leowattana… - World journal of …, 2023 - ncbi.nlm.nih.gov
Significant progress has been achieved in the treatment of metastatic colorectal cancer
(mCRC) patients during the last 20 years. There are currently numerous treatments …
(mCRC) patients during the last 20 years. There are currently numerous treatments …
Immunogenic cell death: an emerging target in gastrointestinal cancers
Immunogenic cell death (ICD) is a regulated form of cell death that induces the activation of
both innate and adaptive immune responses through the release of damage-associated …
both innate and adaptive immune responses through the release of damage-associated …