Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory,
gastrointestinal, and genitourinary tracts; and the skin. Each ecological niche presents a …

Thioredoxin reductase (TrxR) participates in the regulation of redox reactions in organisms.
It works mainly via its substrate molecule, thioredoxin, to maintain the redox balance and …

Unlike proteins, RNA molecules have emerged lately as key players in regulation in
bacteria. Most reviews hitherto focused on the experimental and/or in silico methods used to …

Necrotizing fasciitis, also known as the flesh-eating disease, is a severe invasive infection
associated with very high rates of human morbidity and mortality. It is most commonly …

Infections caused by multidrug-resistant bacteria are a considerable and increasing global
problem. The development of new antibiotics is not keeping pace with the rapid evolution of …

Successful infection depends on the ability of the pathogen to gain nutrients from the host.
The extracellular pathogenic bacterium group A Streptococcus (GAS) causes a vast array of …

Control of virulence gene expression in S. pyogenes is under the charge of 13 two-
component regulatory systems and at least 30 transcriptional regulators known thus far …

The c ontrol ofv irulence gene r egulator (CovR), also called c aspsule s ynthesis r egulator
(CsrR), is critical to how the major human pathogen group A Streptococcus fine-tunes …

The onset of infection and the switch from primary to secondary niches are dramatic
environmental changes that not only alter bacterial transcriptional programs, but also perturb …

Streptococcal species are a diverse group of bacteria which can be found in animals and
humans. Their interactions with host organisms can vary from commensal to pathogenic …