This paper reviews the body of evidence that not only tryptophan and consequent 5-HT
depletion, but also induction of indoleamine 2, 3-dioxygenase (IDO) and the detrimental …

There is extensive bi-directional communication between the brain and the immune system
in both health and disease. In recent years, the role of an altered immune system in the …

Evidence suggests that the hyperammonemia (HA)-induced neuroinflammation and
alterations in the serotonin (5-HT) system may contribute to cognitive decline and anxiety …

Obesity and depression are among the most pressing health problems in the contemporary
world. Obesity and depression share a bidirectional relationship, whereby each condition …

Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could
be associated with the pathophysiology of depression. This study investigated the markers …

It has long been established in traditional forms of medicine and in anecdotal knowledge
that the health of the body and the mind are inextricably linked. Strong and continually …

Objective: To assess the utility of prophylactic administration of antidepressants in
preventing a major depressive episode during antiviral treatment for chronic hepatitis C …

We previously reported that confronting mice to the Unpredictable Chronic Mild Stress
procedure (UCMS) resulted in peripheral and cerebral alterations of the kynurenine pathway …

Both depression and cancer are related to a dysregulation of inflammatory and immune
pathways. Indeed, depression is associated with increased expression of interferon-γ …

Depression is a common side-effect of interferon (IFN)-alpha treatment of hepatitis C virus
(HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might …