Prediction of immunotherapy efficacy and immunomodulatory role of hypoxia in colorectal cancer

Z Zheng, C Bian, H Wang, J Su… - Therapeutic …, 2022 - journals.sagepub.com
Immunotherapy has been used in the clinical treatment of colorectal cancer (CRC); however,
most patients fail to achieve satisfactory survival benefits. Biomarkers with high specificity …

Cross-talk of multiple types of RNA modification regulators uncovers the tumor microenvironment and immune infiltrates in soft tissue sarcoma

L Qi, W Zhang, X Ren, R Xu, Z Yang, R Chen… - Frontiers in …, 2022 - frontiersin.org
Background Soft-tissue sarcoma (STS) represents a rare and diverse cohort of solid tumors,
and encompasses over 100 various histologic and molecular subtypes. In recent years, RNA …

[PDF][PDF] RNA modifications meet tumors

Z Yang, S Zhang, T Xia, Y Fan, Y Shan… - Cancer Management …, 2022 - Taylor & Francis
RNA modifications occur through the whole process of gene expression regulation,
including transcription, translation, and post-translational processes. They are closely …

Development and validation of a cancer-associated fibroblast-derived lncRNA signature for predicting clinical outcomes in colorectal cancer

H Pan, J Pan, J Wu - Frontiers in Immunology, 2022 - frontiersin.org
Cancer-associated fibroblasts (CAFs) are actively involved in cancer progression through
generating extracellular matrix and orchestrating the crosstalk within the tumor …

Crosstalk of eight types of RNA modification regulators defines tumor microenvironments, cancer hallmarks, and prognosis of lung adenocarcinoma

S Mao, Z Chen, Y Wu, H Xiong, X Yuan - Journal of oncology, 2022 - Wiley Online Library
RNA modification has become an exciting underexplored field in recent years. In lung
adenocarcinoma (LUAD), m6A was the best characterized and most studied RNA …

Identification of a novel prognostic signature correlated with epithelial‐mesenchymal transition, N6‐methyladenosine modification, and immune infiltration in colorectal …

X Qu, H Tan, J Mao, M Yang, J Xu, X Yan… - Cancer …, 2023 - Wiley Online Library
Objective Colorectal cancer (CRC) is a commonly diagnosed human malignancy worldwide.
Both epithelial‐mesenchymal transition (EMT) and N6‐methyladenosine (m6A) modification …

Emerging role of RNA modification and long noncoding RNA interaction in cancer

L Yang, L Tang, Q Min, H Tian, L Li, Y Zhao… - Cancer Gene …, 2024 - nature.com
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-
methylguanosine methylation, participates in the occurrence and progression of cancer …

[HTML][HTML] Combination of multiple omics techniques for a personalized therapy or treatment selection

C Massa, B Seliger - Frontiers in Immunology, 2023 - frontiersin.org
Despite targeted therapies and immunotherapies have revolutionized the treatment of
cancer patients, only a limited number of patients have long-term responses. Moreover, due …

Identification of m6A/m5C-related lncRNA signature for prediction of prognosis and immunotherapy efficacy in esophageal squamous cell carcinoma

J Wang, H Ren, C Xu, B Yu, Y Cai, J Wang, X Ni - Scientific Reports, 2024 - nature.com
Abstract N6-methyladenosine (m6A) and 5-methylcytosine (m5C) RNA modifications have
garnered significant attention in the field of epigenetic research due to their close …

[HTML][HTML] Cancer-associated fibroblasts-derived lncRNA signature as a putative biomarker in breast cancer

Z Li, J Yu, C Lv, Z Luo - Frontiers in Oncology, 2022 - frontiersin.org
Long noncoding RNAs (lncRNAs) have been reported to play a key role in regulating tumor
microenvironment and immunity. Cancer-associated fibroblasts (CAFs) are abundant in …