Abdominal pain is the foremost complication of chronic pancreatitis (CP). Pain can be
related to recurrent or chronic inflammation, local complications or neurogenic mechanisms …

Chronic pancreatitis is a progressive fibroinflammatory disease that exists in large-duct
(often with intraductal calculi) or small-duct form. In many patients this disease results from a …

Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts
normal liver functionality. It is a pathological stage in several untreated chronic liver …

Current knowledge about chronic pancreatitis (CP) is limited and there is a particular dearth
of information about the entity known as tropical pancreatitis. A consensus working party …

Tropical chronic pancreatitis (TCP) is a juvenile form of chronic calcific non-alcoholic
pancreatitis, seen almost exclusively in the developing countries of the tropical world. The …

Animprovedknowledgeof the natural history is the indispensible basis for a rational concept
in regard to the diagnosis, classification, understanding andmanagement of pain in chronic …

Clinical outcomes for total-pancreatectomy followed by intraportal islet autotransplantation
(TP-IAT) to treat chronic pancreatitis (CP) are suboptimal due to pancreas inflammation …

Reactive oxygen and nitrogen species (ROS and RNS) play an important role in signal
transduction and cell injury processes. Nitric oxide synthase (NOS)—the key enzyme …

Chronic pancreatitis (CP) is characterized by mononuclear inflammatory cell infiltration and
replacement of the destroyed parenchyma by fibrous tissue. Recently, mast cells have been …

Background Pain in CP results from inflammation and neuroimmune alterations that are
associated with oxidative stress, among other mechanisms. This is marked by depletion of …