The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

Abstract The pyrrolo [2, 1‐c][1, 4] benzodiazepines (PBDs) are a family of sequence‐
selective DNA minor‐groove binding agents that form a covalent aminal bond between their …

This article reviews the investigations undertaken into platinum (IV) antitumour compounds
since Barnett Rosenberg first noted the activity of platinum (IV) complexes. The chemical …

The application of inorganic chemistry to medicine is a rapidly developing field, and novel
therapeutic and diagnostic metal complexes are now having an impact on medical practice …

In the next two decades, the world is expected to see around 20 million cases of cancer.
Moreover, the types of cancer will vary considerably from country to other. Therefore, all …

Metal coordination compounds with 'slow'metal-ligand exchange rates, comparable to those
of cell division processes, often appear to be highly active in killing cancer cell lines. This is …

Metal-based coordination compounds have been used throughout the history of human
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …

Publisher Summary Biomedical inorganic chemistry “Elemental Medicine” is an important
new area of chemistry. Platinum complexes are now among the most widely used drugs for …

The synthesis and evaluation of the novel head-to-head bisbenzimidazole compound 2, 2-
bis [4 '-(3 ''-dimethylamino-1 ''-propyloxy) phenyl]-5, 5-bi-1 H-benzimidazole is described. An …