Retinoic Acid Upregulates METTL14 Expression and the m6A Modification Level to Inhibit the Proliferation of Embryonic Palate Mesenchymal Cells in Cleft Palate …

Y Zhu, Y Zhang, Y Jiang, H Cai, J Liang, H Li… - International Journal of …, 2024 - mdpi.com
Cleft palate only (CPO) is one of the most common craniofacial birth defects. Environmental
factors can induce cleft palate by affecting epigenetic modifications such as DNA …

DeepFace: Deep learning-based framework to contextualize orofacial cleft-related variants during human embryonic craniofacial development

Y Dai, T Itai, G Pei, F Yan, Y Chu, X Jiang… - Human Genetics and …, 2024 - cell.com
Orofacial clefts (OFC) are among the most common human congenital birth defects.
Previous multiethnic studies have identified dozens of associated loci for both cleft lip with or …

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease

A Liu, C Citu, N Enduru, X Chen, AM Manuel, T Sinha… - bioRxiv, 2024 - biorxiv.org
Sporadic early-onset Alzheimer's disease (sEOAD) represents a significant but less-studied
subtype of Alzheimer's disease (AD). Here, we generated a single-nucleus multiome atlas …