Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …

Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being
responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic …

Zebrafish are increasingly being utilized as a model system to investigate the function of the
growing list of risk genes associated with neurodevelopmental disorders. This is due in large …

For the past few years there has been an exponential increase in the use of animal models
to confirm the pathogenicity of candidate disease-causing genetic variants found in patients …

Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development
are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are …

Autism spectrum disorders (ASDs) are a highly variable and complex set of neurological
disorders that alter neurodevelopment and cognitive function, which usually presents with …

The zebrafish represents an excellent compromise between system complexity and practical
simplicity, features that make it useful for modeling and mechanistic analysis of complex …

A phenomenon of genetic compensation is commonly observed when an organism with a
disease-bearing mutation shows incomplete penetrance of the disease phenotype. Such …

Alzheimer's disease (AD) has become increasingly prevalent in the elderly population
across the world. It's pathophysiological markers such as overproduction along with the …