As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

Despite relentless efforts to improve outcome, the prognosis of glioblastoma (GBM) remains
poor. Standard therapy at first diagnosis consists of maximal safe surgical resection followed …

Background Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and
Crohn's disease (CD), is a chronic, progressive, and recurrent intestinal condition that poses …

Background Methamphetamine (METH) is a highly addictive stimulant that has become one
of the top five risk substances cause deaths from substance abuse. METH exposure …

In the central nervous system (CNS), the myelin sheath ensures efficient interconnection
between neurons and contributes to the regulation of the proper function of neuronal …

Microglia are dynamic guardians of neural tissue and the resident immune cells of the
central nervous system (CNS). The disease-associated microglial signature (DAM), also …

We report a microglial phagocytosis/cell health high‐content assay that has been used to
test small molecule chemical probes and support our drug discovery projects targeting …

Phagocytes maintain homeostasis in a healthy brain. Upon injury, they are essential for
repairing damaged tissue, recruiting other immune cells, and releasing cytokines as the first …

Post-traumatic stress disorder (PTSD) is a debilitating mental health disease related to
traumatic experience, and its treatment outcomes are unsatisfactory. Accumulating research …

Previous studies have found that ferroptosis plays an important role in a variety of
neurological diseases. However, the precise role of ferroptosis in the multiple sclerosis …