Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Traditional diagnostic systems went beyond empirical evidence on the structure of mental
health. Consequently, these diagnoses do not depict psychopathology accurately, and their …

Mental ill‐health represents the main threat to the health, survival and future potential of
young people around the world. There are indications that this is a rising tide of vulnerability …

The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …

Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …

This narrative state-of-the-art review paper describes the progress in the understanding and
treatment of Posttraumatic Stress Disorder (PTSD). Over the last four decades, the scientific …

The Hierarchical Taxonomy of Psychopathology (HiTOP) has emerged out of the
quantitative approach to psychiatric nosology. This approach identifies psychopathology …

Mental disorder classification provides a definitional framework that underlies applied
clinical and research efforts to understand, assess, predict, prevent and ameliorate the …

Objective This paper outlines the evidence base for early intervention for eating disorders;
provides a global overview of how early intervention for eating disorders is provided in …