Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect of chemotherapy
that is frequently experienced by patients receiving treatment for cancer. CIPN is caused by …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …

Introduction: Variability of drug response is an important consideration in clinical medicine. A
major determinant of drug response variability is hepatic cytochrome P450 oxidase …

Predicting drug-target interactions (DTIs) is essential for both drug discovery and drug
repositioning. Recently, deep learning methods have achieved relatively significant …

Safe and effective use of drugs requires an understanding of metabolism and transport. We
identified the 100 most prescribed drugs in six countries and conducted a literature search …

Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs,
chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for …

Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global
epidemic. In order to achieve optimal glucose control, it is often necessary to rely on …

NO has many physiological roles; in inflammation, pain, rheumatoid arthritis, immune
system, gastroprotection, as antioxidant and reported to be a free radical scavenger …