Nanoscale lipid vesicles are attractive vehicles for drug delivery. Although often considered
as soft nanoparticles in terms of mechanical deformability, the fluidic nature of the lipid …

Liposomes are widely used as synthetic analogues of cell membranes and for drug delivery.
Lipid-binding DNA nanostructures can modify the shape, porosity and reactivity of …

Protein-based drugs are a promising class of therapeutics, but poor membrane permeability
typically limits their application to extracellular receptors. Delivery strategies that can …

Lipid-based nanoparticles have made a breakthrough in clinical disease as delivery
systems due to their biocompatibility, thermal and long-term stability, high loading ability …

Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the
plasma membrane impairs synaptic transmission. However, the molecular mechanisms by …

Cholesterol is an important component for cell physiology. It regulates the fluidity of cell
membranes and determines the physical and biochemical properties of proteins. In the …

The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their
infection by an incompletely understood mechanism. We have previously reported that …

Ebolavirus (EBOV), an enveloped filamentous RNA virus causing severe hemorrhagic fever,
enters cells by macropinocytosis and releases its genetic material into the cytoplasm after …

The brain contains the highest concentration of cholesterol in the human body, which
emphasizes the importance of cholesterol in brain physiology. Cholesterol is involved in …

Genetic alterations in the LRRK2 gene, encoding leucine-rich repeat kinase 2, are a
common risk factor for Parkinson's disease. How LRRK2 alterations lead to cell pathology is …