Inflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate
immune signal receptors to sense pathogens and initiate inflammatory responses under …

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …

Blood-brain barrier disruption plays an important role in central nervous system diseases.
This review provides information on the role of mitochondrial oxidative stress in brain …

Endothelial dysfunction often accompanies sepsis. We aimed to explore the role of PCSK9
in septic endothelial dysfunction. Sepsis was induced by lipopolysaccharide (LPS) treatment …

Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main
causes of maternal death. Persistent inflammation in the endothelium stimulates the …

Endothelial dysfunction develops gradually with age, and is the foundation of many age-
related diseases in the elderly. The purpose of this study was to investigate the role of the …

Sepsis is an uncontrolled host response to infection. In some cases, it progresses to multi-
organ insufficiency, leading to septic shock and increased risk of mortality. Various organ …

Extensive vascular endothelial dysfunction usually occurs in sepsis, resulting in high
mortality. The purpose of this study was therefore to investigate the role of AMP-dependent …

It has been revealed that widespread vascular endothelial dysfunction occurs in septic
shock, ultimately resulting in multiple organ failure. The mitochondrial deacetylase sirtuin 3 …

Background Salidroside (SAL) is a bioactive compound extracted from Rhodiola rosea with
various biological properties. This study was designed to explore the functions of SAL on the …