Abstract PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules
consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead” to …

Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …

E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and
subsequent degradation, are attractive drug targets due to their exquisite substrate …

Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse
and often opposing biological activities. The diversity in response to this simple diatomic …

Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor
that is expressed in all metazoan organisms and is composed of HIF-1α and HIF-1β …

In this review we examine the mechanisms (causes) underlying the increased glucose
consumption observed in tumors within a teleological context (consequences). In other …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Nitric oxide's expansive physiological and regulatory roles have driven the development of
therapies for human disease that would benefit from exogenous NO administration. Already …

Most cells have the inherent capacity to shift their reliance on glycolysis relative to oxidative
metabolism, and studies in model systems have shown that targeting such shifts may be …

The oxygen sensitive α-subunit of the hypoxia-inducible factor-1 (HIF-1) is a major trigger of
the cellular response to hypoxia. Although the posttranslational regulation of HIF-1α by …