Role of vascular endothelial growth factor (VEGF) in human embryo implantation: clinical implications

X Guo, H Yi, TC Li, Y Wang, H Wang, X Chen - Biomolecules, 2021 - mdpi.com
Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a
critical role in various physiological and pathological processes. VEGF also contributes to …

[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation

A Uemura, M Fruttiger, PA d'Amore, S De Falco… - Progress in retinal and …, 2021 - Elsevier
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

Biomolecular markers of recurrent implantation failure—A review

AE Mrozikiewicz, M Ożarowski… - International Journal of …, 2021 - mdpi.com
Currently, infertility affects 8–12% of reproductive age couples worldwide, a problem that
also affects women suffering from recurrent implantation failure (RIF). RIF is a complex …

[HTML][HTML] Retinopathy of prematurity: A review of pathophysiology and signaling pathways

M Fevereiro-Martins, C Marques-Neves… - survey of …, 2023 - Elsevier
Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

[HTML][HTML] Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration

I Van Hove, TT Hu, K Beets, T Van Bergen… - Progress in retinal and …, 2021 - Elsevier
Integrins are a class of transmembrane receptors that are involved in a wide range of
biological functions. Dysregulation of integrins has been implicated in many pathological …

[HTML][HTML] Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease

J Brinks, EHC Van Dijk, I Klaassen… - Progress in retinal and …, 2022 - Elsevier
The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of
chorioretinal diseases, many of which are poorly understood. Recent advances in the field of …

Aflibercept regulates retinal inflammation elicited by high glucose via the PlGF/ERK pathway

F Lazzara, A Fidilio, CBM Platania… - Biochemical …, 2019 - Elsevier
Diabetic retinopathy (DR) is a secondary complication of diabetes. DR can cause
irreversible blindness, and its pathogenesis is considered multifactorial. DR can progress …

Stabilization of HIF-1α in human retinal endothelial cells modulates expression of miRNAs and proangiogenic growth factors

F Lazzara, MC Trotta, CBM Platania… - Frontiers in …, 2020 - frontiersin.org
Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the
triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic …

Mechanisms of acquired resistance to anti-VEGF therapy for neovascular eye diseases

D Sharma, I Zachary, H Jia - Investigative Ophthalmology & …, 2023 - iovs.arvojournals.org
Purpose: The purpose of this study was to evaluate clinical reports of response-loss in
patients with neovascular eye diseases, such as neovascular age-related macular …

[HTML][HTML] Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function

G Bai, X Jiang, J Qin, Y Zou, W Zhang, T Teng… - Environment …, 2022 - Elsevier
Glyphosate-based herbicides (GBHs) are the most widely used pesticide worldwide and can
provoke placental injury. However, whether and how GBHs damage angiogenesis in the …