Chronic urticaria (CU) is a mast cell (MC)‐dependent disease with limited therapeutic
options. Current management strategies are directed at inhibiting IgE‐mediated activation of …

Autoimmune diseases have a prevalence of approximately 7 to 9% and are classified as
either organ‐specific diseases, including type I diabetes, multiple sclerosis, inflammatory …

It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a
quick response to the various stimulants, including—but not limited to—allergens, pathogen …

Despite an increasing burden of osteoarthritis in developed societies, target discovery has
been slow and there are currently no approved disease-modifying osteoarthritis drugs. This …

Mast cells (MCs) are important sensor and effector cells of the immune system that are
involved in many physiological and pathological conditions. Increasing evidence suggests …

PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …

Chronic inflammation is implicated in numerous human pathologies. In particular, low-grade
inflammation is currently recognized as an important mechanism of osteoarthritis (OA), at …

Osteoarthritis (OA) is a chronic and debilitating disease of the knee joint. OA of the knee is
initiated by physical damage and accumulated oxidative stress, followed by an exaggerated …

Mast cells are an essential part of the immune system and are best known as important
modulators of allergic and anaphylactic immune responses. Upon activation, mast cells …

Mast cells (MC) are key drivers of allergic and inflammatory diseases. Sialic acid-binding
immunoglobulin-like lectin (Siglec)-6 is an immunoregulatory receptor found on MCs. While …