14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis

W Fu, A Hettinghouse, Y Chen, W Hu, X Ding… - Annals of the …, 2021 - ard.bmj.com
Objectives Osteoarthritis (OA) is the most common joint disease; however, the indeterminate
nature of mechanisms by which OA develops has restrained advancement of therapeutic …

RNA-seq characterization of histamine-releasing mast cells as potential therapeutic target of osteoarthritis

X Zhao, S Younis, H Shi, S Hu, A Zia, HH Wong… - Clinical …, 2022 - Elsevier
Objective Mast cells in the osteoarthritis (OA) synovium correlate with disease severity. This
study aimed to further elucidate the role of mast cells in OA by RNA-Seq analysis and …

[HTML][HTML] The inhibitory receptor Siglec-8 interacts with FcεRI and globally inhibits intracellular signaling in primary mast cells upon activation

W Korver, A Wong, S Gebremeskel, GL Negri… - Frontiers in …, 2022 - frontiersin.org
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory
diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory …

Increased risk of osteoarthritis in patients with atopic disease

MC Baker, K Sheth, R Lu, D Lu… - Annals of the …, 2023 - ard.bmj.com
Objectives To determine the incidence of osteoarthrits (OA) in patients with atopic disease
compared with matched non-exposed patients. Methods We conducted a retrospective …

[HTML][HTML] The Corpus Adiposum Infrapatellare (Hoffa's Fat Pad)—the role of the infrapatellar fat pad in osteoarthritis pathogenesis

S Braun, F Zaucke, M Brenneis, AE Rapp, P Pollinger… - Biomedicines, 2022 - mdpi.com
In recent years, the infrapatellar fat pad (IFP) has gained increasing research interest. The
contribution of the IFP to the development and progression of knee osteoarthritis (OA) …

Smoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 m6 modification

J Tu, W Li, PM Hansbro, Q Yan, X Bai, C Donovan… - Molecular Therapy, 2023 - cell.com
Although cigarette smoking (CS) and low back pain (LBP) are common worldwide, their
correlations and the mechanisms of action remain unclear. We have shown that excessive …

The role of extracellular vesicles in osteoarthritis treatment via microenvironment regulation

H Yin, M Li, G Tian, Y Ma, C Ning, Z Yan, J Wu… - Biomaterials …, 2022 - spj.science.org
Osteoarthritis (OA) is a degenerative joint disease that is common among the middle-aged
and older populations, causes patients to experience recurrent pain in their joints and …

Tick bites, IgE to galactose‐alpha‐1, 3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome

JM Wilson, L Erickson, M Levin, SM Ailsworth… - Allergy, 2024 - Wiley Online Library
The recent recognition of a syndrome of tick‐acquired mammalian meat allergy has
transformed the previously held view that mammalian meat is an uncommon allergen. The …

[HTML][HTML] GEO 数据库联合机器学习策略识别骨关节炎特征性lncRNA 分子标志物及实验验证

巧周, 健刘, 凌忻, 妍妍方, 亚军齐… - Journal of Sichuan …, 2023 - ncbi.nlm.nih.gov
GEO数据库联合机器学习策略识别骨关节炎特征性lncRNA分子标志物及实验验证- PMC Back to
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[HTML][HTML] The immune role of the intestinal microbiome in knee osteoarthritis: a review of the possible mechanisms and therapies

C Sun, X Zhou, T Guo, J Meng - Frontiers in Immunology, 2023 - frontiersin.org
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage
damage and synovial inflammation and carries an enormous public health and economic …