MicroRNAs (miRNAs) are small regulatory molecules post-transcriptionally suppressing
mRNA activity. Many miRNAs in various organisms have been cloned but many unknown …

Background and Objective Atrial fibrillation (AF), the most common cardiac arrhythmia,
typically increases with age. Oral anticoagulants (OACs) are the cornerstone of treatment to …

Effective stroke prevention with oral anticoagulation (OAC) is the cornerstone of the
management of patients with atrial fibrillation. The use of OAC reduces the risk of stroke and …

Background The prevalence and incidence of atrial fibrillation (AF) increase with age.
However, older patients often are denied oral anticoagulation (OAC), especially if they are …

Randomized controlled trials (RCTs) are preferred by payers for health technology
assessments and coverage decisions. However, the inclusion of a highly selective patient …

ABSTRACT Introduction Oral anticoagulants (OACs) are the cornerstone of stroke
prevention in atrial fibrillation (AF), but prescribing decisions in older people are …

Background Although a growing number of very elderly patients with atrial fibrillation (AF),
multiple conditions, and polypharmacy receive direct oral anticoagulants (DOACs), few …

Direct oral anticoagulants (DOACs) have been demonstrated to be more effective and safer
than vitamin-K antagonist (VKA) for stroke prevention in patients with nonvalvular atrial …

BACKGROUND: The very elderly (≥ 80 years) are at high risk of nonvalvular atrial
fibrillation and thromboembolism. Given its recent approval, the comparative effectiveness …

Anticoagulation therapy is an important method of preventing stroke in individuals with atrial
fibrillation (AF). Atrial fibrillation is a quivering or irregular heartbeat that can lead to blood …