Presbycusis: an update on cochlear mechanisms and therapies

J Wang, JL Puel - Journal of clinical medicine, 2020 - mdpi.com
Age-related hearing impairment (ARHI), also referred to as presbycusis, is the most common
sensory impairment seen in the elderly. As our cochlea, the peripheral organ of hearing …

Current concepts in age-related hearing loss: epidemiology and mechanistic pathways

T Yamasoba, FR Lin, S Someya, A Kashio, T Sakamoto… - Hearing research, 2013 - Elsevier
Age-related hearing loss (AHL), also known as presbycusis, is a universal feature of
mammalian aging and is characterized by a decline of auditory function, such as increased …

Single-cell transcriptomic atlas of mouse cochlear aging

G Sun, Y Zheng, X Fu, W Zhang, J Ren, S Ma… - Protein & …, 2023 - academic.oup.com
Progressive functional deterioration in the cochlea is associated with age-related hearing
loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains …

Mechanisms of sensorineural cell damage, death and survival in the cochlea

ACY Wong, AF Ryan - Frontiers in aging neuroscience, 2015 - frontiersin.org
The majority of acquired hearing loss, including presbycusis, is caused by irreversible
damage to the sensorineural tissues of the cochlea. This article reviews the intracellular …

Impact of aging on the auditory system and related cognitive functions: a narrative review

DMP Jayakody, PL Friedland, RN Martins… - Frontiers in …, 2018 - frontiersin.org
Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects
approximately one-third of the world's population. The peripheral and central hearing …

Targeting dysregulation of redox homeostasis in noise-induced hearing loss: oxidative stress and ROS signaling

AR Fetoni, F Paciello, R Rolesi, G Paludetti… - Free Radical Biology and …, 2019 - Elsevier
Hearing loss caused by exposure to recreational and occupational noise remains a
worldwide disabling condition and dysregulation of redox homeostasis is the hallmark of …

New treatment options for hearing loss

U Müller, PG Barr-Gillespie - Nature reviews Drug discovery, 2015 - nature.com
Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Role of antioxidants in prevention of age-related hearing loss: a review of literature

E Tavanai, G Mohammadkhani - European Archives of Oto-Rhino …, 2017 - Springer
Age-related hearing loss (ARHL), also known as presbycusis, is one of the most prevalent
chronic degenerative conditions. It is characterized by a decline in auditory function. ARHL …

[HTML][HTML] A review of new insights on the association between hearing loss and cognitive decline in ageing

S Fortunato, F Forli, V Guglielmi… - Acta …, 2016 - ncbi.nlm.nih.gov
Age-related hearing loss (ARHL) has a multifactorial pathogenesis and it is an inevitable
hearing impairment associated with reduction of communicative skills related to ageing …

Progress on mechanisms of age-related hearing loss

W Yang, X Zhao, R Chai, J Fan - Frontiers in neuroscience, 2023 - frontiersin.org
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly
people worldwide. It typically presents as progressive, irreversible, and usually affects the …