Early detection of cancer

D Crosby, S Bhatia, KM Brindle, LM Coussens, C Dive… - Science, 2022 - science.org
Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …

Cancer models in preclinical research: A chronicle review of advancement in effective cancer research

H Sajjad, S Imtiaz, T Noor, YH Siddiqui… - Animal Models and …, 2021 - Wiley Online Library
Cancer is a major stress for public well‐being and is the most dreadful disease. The models
used in the discovery of cancer treatment are continuously changing and extending toward …

Hydrogels to engineer tumor microenvironments in vitro

K Fernando, LG Kwang, JTC Lim, ELS Fong - Biomaterials Science, 2021 - pubs.rsc.org
In recent years, hydrogel-based three-dimensional tumor models have become increasingly
mainstream for cancer research. Hydrogels enable recapitulation of biochemical and …

Synthetic matrix scaffolds engineer the in vivo tumor immune microenvironment for immunotherapy screening

MJ O'Melia, A Mulero‐Russe, J Kim, A Pybus… - Advanced …, 2022 - Wiley Online Library
Immunotherapy has emerged as one of the most powerful anti‐cancer therapies but is
stymied by the limits of existing preclinical models with respect to disease latency and …

Advances in 3D bioprinting for the biofabrication of tumor models

MG Sánchez-Salazar, MM Álvarez… - Bioprinting, 2021 - Elsevier
Cancer research depends on the challenging task of producing representative and reliable
models of human disease; these have largely been limited to mouse models or human …

[HTML][HTML] Patient-derived organoid analysis of drug resistance in precision medicine: is there a value?

A Abugomaa, M Elbadawy - Expert Review of Precision Medicine …, 2020 - Taylor & Francis
Cancer is the main health problem with high morbidity and mortality. The worldwide annual
incidence and deaths from cancers are estimated in millions [1, 2]. Hence, cancer therapy …

[HTML][HTML] In vitro cancer models: a closer look at limitations on translation

N Antunes, B Kundu, SC Kundu, RL Reis, V Correlo - Bioengineering, 2022 - mdpi.com
In vitro cancer models are envisioned as high-throughput screening platforms for potential
new therapeutic discovery and/or validation. They also serve as tools to achieve …

[HTML][HTML] Conditional Cell Reprogramming and Air–Liquid Interface Modeling Life Cycle of Oncogenic Viruses (HPV and EBV) in Epithelial Cells and Virus-Associated …

AQ Rani, D Nurmemet, J Liffick, A Khan, D Mitchell, J Li… - Viruses, 2023 - mdpi.com
Several oncogenic viruses are associated with approximately 20% of human cancers.
Experimental models are crucial for studying the pathogenicity and biological aspects of …

[HTML][HTML] Playing on the dark side: SMYD3 acts as a cancer genome keeper in gastrointestinal malignancies

P Sanese, C Fasano, C Simone - Cancers, 2021 - mdpi.com
Simple Summary The activity of SMYD3 in promoting carcinogenesis is currently under
debate. Growing evidence seems to confirm that SMYD3 overexpression correlates with …

[PDF][PDF] Can computers conceive the complexity of cancer to cure it? Using artificial intelligence technology in cancer modelling and drug discovery

RC Adams, B Rashidieh - Mathematical Biosciences and …, 2020 - researchgate.net
Drug discovery and the development of safe and effective therapeutics is an intricate
procedure, further complicated in the context of cancer research by the inherent …