Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
[HTML][HTML] Investigating the pathogenesis of severe malaria: a multidisciplinary and cross-geographical approach
SC Wassmer, TE Taylor, PK Rathod… - The American journal …, 2015 - ncbi.nlm.nih.gov
More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of
severe malaria is still not well understood. The majority of malaria cases are caused by …
severe malaria is still not well understood. The majority of malaria cases are caused by …
Severe malaria is associated with parasite binding to endothelial protein C receptor
Sequestration of Plasmodium falciparum-infected erythrocytes in host blood vessels is a key
triggering event in the pathogenesis of severe childhood malaria, which is responsible for …
triggering event in the pathogenesis of severe childhood malaria, which is responsible for …
Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season
CM Andrade, H Fleckenstein, R Thomson-Luque… - Nature Medicine, 2020 - nature.com
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …
endemic regions, where water availability limits mosquito vectors to only part of the year …
[HTML][HTML] The structural basis for CD36 binding by the malaria parasite
CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …
[HTML][HTML] Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria
SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …
the world's population at risk of Plasmodium infections. The development of an effective …
[HTML][HTML] Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria
F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
Malaria's deadly grip: cytoadhesion of Plasmodium falciparum‐infected erythrocytes
Cytoadhesion of P lasmodium falciparum‐infected erythrocytes to host microvasculature is a
key virulence determinant. Parasite binding is mediated by a large family of clonally variant …
key virulence determinant. Parasite binding is mediated by a large family of clonally variant …
[HTML][HTML] Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis
The most polymorphic gene family in P. falciparum is the∼ 60 var genes distributed across
parasite chromosomes, both in the subtelomeres and in internal regions. They encode …
parasite chromosomes, both in the subtelomeres and in internal regions. They encode …
Efficiently inferring community structure in bipartite networks
Bipartite networks are a common type of network data in which there are two types of
vertices, and only vertices of different types can be connected. While bipartite networks …
vertices, and only vertices of different types can be connected. While bipartite networks …