Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

The non-essential amino acid cysteine is used within cells for multiple processes that rely on
the chemistry of its thiol group. Under physiological conditions, many non-transformed …

Large-scale untargeted lipidomics experiments involve the measurement of hundreds to
thousands of samples. Such data sets are usually acquired on one instrument over days or …

Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from
oxidative phosphorylation to predominantly glycolytic pathways to support rapid growth is …

Folate metabolism is crucial for many biochemical processes, including purine and
thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and …

Availability of the amino acid methionine shows remarkable effects on the physiology of
individual cells and whole organisms. For example, most cancer cells, but not normal cells …

Tumor progression upon treatment arises from preexisting resistant cancer cells and/or
adaptation of persister cancer cells committing to an expansion phase. Here, we show that …

Since triple-negative breast cancer (TNBC) was first defined over a decade ago, increasing
studies have focused on its genetic and molecular characteristics. Patients diagnosed with …