Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Background: The dopaminergic system has been associated with the progression of
Alzheimer's disease. But previous studies found inconsistent results regarding the …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and non-
motor symptoms which relentlessly and progressively lead to substantial disability and …

Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

Simple Summary Prostate cancer, after lung cancer, is the leading cause of death among
men. The incidence rate of prostate cancer varies worldwide between regions and …

AG protein-coupled receptor heteromer that fulfills the established criteria for its existence in
vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors …

Herein, a novel series of multireceptor ligands was developed as polypharmacological
antipsychotic agents using the designed multiple ligand approach between dopamine …

Melanoma is one of the leading fatal forms of cancer, yet from a treatment perspective, we
have minimal control over its reoccurrence and resistance to current pharmacotherapies …