This review is an account of how pulmonary damage caused by cigarette smoke and other
environmental toxins can incite inflammatory and immunologic reactions that culminate in …

There has been much recent interest in the role of the vitamin D axis in lung disease, which
includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also …

The success of genome-wide association (GWA) studies for the detection of sequence
variation affecting complex traits in human has spurred interest in the use of large-scale high …

Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …

The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a
measure used to diagnose airflow obstruction and is highly heritable. We performed a …

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and
sacroiliac joints. It causes significant disability and is associated with a number of other …

Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are
strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including …

Interindividual variability in cytochrome P450 3A4 (CYP3A4) is believed to be largely
heritable; however, predictive genetic factors have remained scarce. Using a candidate …

The glutathionylation of intracellular protein thiols can protect against irreversible oxidation
and can act as a redox switch regulating metabolic pathways. In this study we discovered …

Abstract Background The Framingham Heart Study (FHS), founded in 1948 to examine the
epidemiology of cardiovascular disease, is among the most comprehensively characterized …