Primary structure of glycans by NMR spectroscopy

C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

Targeting tumor glycans for cancer therapy: successes, limitations, and perspectives

N Berois, A Pittini, E Osinaga - Cancers, 2022 - mdpi.com
Simple Summary Aberrant glycosylation is a common feature of many cancers, and it plays
crucial roles in tumor development and biology. Cancer progression can be regulated by …

Structural basis for human coronavirus attachment to sialic acid receptors

MA Tortorici, AC Walls, Y Lang, C Wang, Z Li… - Nature structural & …, 2019 - nature.com
Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly
pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein …

The structural basis of accelerated host cell entry by SARS‐CoV‐2

M Seyran, K Takayama, VN Uversky… - The FEBS …, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the pandemic coronavirus disease 2019 (COVID‐19) that exhibits an overwhelming …

Mapping the acetylamino and carboxyl groups on glycans by engineered α-hemolysin nanopores

B Xia, J Fang, S Ma, M Ma, G Yao, T Li… - Journal of the …, 2023 - ACS Publications
Glycan is a crucial class of biological macromolecules with important biological functions.
Functional groups determine the chemical properties of glycans, which further affect their …

The distinct roles of sialyltransferases in cancer biology and onco-immunology

M Hugonnet, P Singh, Q Haas… - Frontiers in …, 2021 - frontiersin.org
Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Biological functions and analytical strategies of sialic acids in tumor

X Zhou, G Yang, F Guan - Cells, 2020 - mdpi.com
Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …

Siglec signaling in the tumor microenvironment

EJH van Houtum, C Büll, LAM Cornelissen… - Frontiers in …, 2021 - frontiersin.org
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that
recognize sialoglycans–sialic acid containing glycans that are abundantly present on cell …

[PDF][PDF] Wang

Y Wang - Jia Z, Yi Q, Song L. The various components implied …, 2018 - tranassoc.com
Systems and methods are disclosed for communicating data in an integrated sensor network
having one or more nodes coupled to an optical sensor network and a radio frequency …

Targeted glycan degradation potentiates cellular immunotherapy for solid tumors

J Wu, X Wang, Y Huang, Y Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Immune cell–based cancer therapies, such as chimeric antigen receptor T (CAR-T)-cell
immunotherapy, have demonstrated impressive potency against hematological tumors …