Primary structure of glycans by NMR spectroscopy
C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …
important glycoconjugates and a characteristic aspect is that their structures in many …
Targeting tumor glycans for cancer therapy: successes, limitations, and perspectives
N Berois, A Pittini, E Osinaga - Cancers, 2022 - mdpi.com
Simple Summary Aberrant glycosylation is a common feature of many cancers, and it plays
crucial roles in tumor development and biology. Cancer progression can be regulated by …
crucial roles in tumor development and biology. Cancer progression can be regulated by …
Structural basis for human coronavirus attachment to sialic acid receptors
Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly
pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein …
pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein …
The structural basis of accelerated host cell entry by SARS‐CoV‐2
M Seyran, K Takayama, VN Uversky… - The FEBS …, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the pandemic coronavirus disease 2019 (COVID‐19) that exhibits an overwhelming …
the pandemic coronavirus disease 2019 (COVID‐19) that exhibits an overwhelming …
Mapping the acetylamino and carboxyl groups on glycans by engineered α-hemolysin nanopores
B Xia, J Fang, S Ma, M Ma, G Yao, T Li… - Journal of the …, 2023 - ACS Publications
Glycan is a crucial class of biological macromolecules with important biological functions.
Functional groups determine the chemical properties of glycans, which further affect their …
Functional groups determine the chemical properties of glycans, which further affect their …
The distinct roles of sialyltransferases in cancer biology and onco-immunology
M Hugonnet, P Singh, Q Haas… - Frontiers in …, 2021 - frontiersin.org
Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …
Biological functions and analytical strategies of sialic acids in tumor
Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …
Siglec signaling in the tumor microenvironment
EJH van Houtum, C Büll, LAM Cornelissen… - Frontiers in …, 2021 - frontiersin.org
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that
recognize sialoglycans–sialic acid containing glycans that are abundantly present on cell …
recognize sialoglycans–sialic acid containing glycans that are abundantly present on cell …
Targeted glycan degradation potentiates cellular immunotherapy for solid tumors
J Wu, X Wang, Y Huang, Y Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Immune cell–based cancer therapies, such as chimeric antigen receptor T (CAR-T)-cell
immunotherapy, have demonstrated impressive potency against hematological tumors …
immunotherapy, have demonstrated impressive potency against hematological tumors …