Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …

Bone regeneration is a highly synchronized process that requires multiple biochemical,
bioelectrical, mechanical, and other physiological cues. The restoration and delivery of …

In recent years, increasing attention has been paid to the pharmacological efficacy of
tannins. Tannic acid (TA), the simplest hydrolysable tannin that has been approved by the …

Background Macrophage M1 polarization plays a pivotal role in inflammatory diseases.
Progranulin (PGRN) has potential anti-inflammation action, however, the effect of PGRN on …

The extracellular signal-regulated kinases 1/2 (ERK) are central signaling components that
regulate stimulated cellular processes such as proliferation and differentiation. When …

Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which
seriously reduces the quality of life of patients and places a heavy economic burden on their …

Three main inflammatory signaling pathways include nuclear factor‐κB (NF‐κB), Janus
kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and mitogen …

Background Despite advances in research on neurodegenerative diseases, the
pathogenesis and treatment response of neurodegenerative diseases remain unclear …