The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum

JM Moscarello, MA Penzo - Nature Neuroscience, 2022 - nature.com
In nature, animals display defensive behaviors that reflect the spatiotemporal distance of
threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have …

Brainstem circuits for locomotion

R Leiras, JM Cregg, O Kiehn - Annual review of neuroscience, 2022 - annualreviews.org
Locomotion is a universal motor behavior that is expressed as the output of many integrated
brain functions. Locomotion is organized at several levels of the nervous system, with …

Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice

JM Cregg, SK Sidhu, R Leiras, O Kiehn - Nature Neuroscience, 2024 - nature.com
The basal ganglia are essential for executing motor actions. How the basal ganglia engage
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …

Defensive responses: Behaviour, the brain and the body

YT Tseng, B Schaefke, P Wei, L Wang - Nature Reviews Neuroscience, 2023 - nature.com
Most animals live under constant threat from predators, and predation has been a major
selective force in shaping animal behaviour. Nevertheless, defence responses against …

[HTML][HTML] A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae

BN Imambocus, F Zhou, A Formozov, A Wittich… - Current Biology, 2022 - cell.com
Animals display selective escape behaviors when faced with environmental threats.
Selection of the appropriate response by the underlying neuronal network is key to …

Flexible inhibitory control of visually evoked defensive behavior by the ventral lateral geniculate nucleus

A Fratzl, AM Koltchev, N Vissers, YL Tan… - Neuron, 2021 - cell.com
Animals can choose to act upon, or to ignore, sensory stimuli, depending on circumstance
and prior knowledge. This flexibility is thought to depend on neural inhibition, through …

[HTML][HTML] The aging mouse brain: cognition, connectivity and calcium

CI Radulescu, V Cerar, P Haslehurst, M Kopanitsa… - Cell calcium, 2021 - Elsevier
Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal
and molecular processes. Technological innovations now allow for parallel investigation of …

Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus

Z Xie, H Gu, M Huang, X Cheng, C Shang, T Tao… - Nature …, 2022 - nature.com
Innate defensive behaviors triggered by environmental threats are important for animal
survival. Among these behaviors, defensive attack toward threatening stimuli (for example …

A cortico-collicular circuit for orienting to shelter during escape

D Campagner, R Vale, YL Tan, P Iordanidou… - Nature, 2023 - nature.com
When faced with predatory threats, escape towards shelter is an adaptive action that offers
long-term protection against the attacker. Animals rely on knowledge of safe locations in the …

Divergent outputs of the ventral lateral geniculate nucleus mediate visually evoked defensive behaviors

LD Salay, AD Huberman - Cell reports, 2021 - cell.com
Rapid alternations between exploration and defensive reactions require ongoing risk
assessment. How visual cues and internal states flexibly modulate the selection of behaviors …