Abstract 3D-printed composite scaffolds have emerged as an alternative to deal with existing
limitations when facing bone reconstruction. The aim of the study was to systematically …

Bone tissue engineering (BTE) represents a multidisciplinary research field involving many
aspects of biology, engineering, material science, clinical medicine and genetics to create …

Regeneration of severe bone defects remains an enormous challenge in clinic. Developing
regenerative scaffolds to directionally guide bone growth is a potential strategy to overcome …

The positive regulation of bone-forming osteoblast activity and the negative feedback
regulation of osteoclastic activity are equally important in strategies to achieve successful …

In bone tissue engineering research, bioreactors designed for replicating the main features
of the complex native environment represent powerful investigation tools. Moreover, when …

The reconstruction of critical‐size bone defects in long bones remains a challenge for
clinicians. A new osteoinductive medical device is developed here for long bone repair by …

Biophysical stimulus quantifies the osteoinductivity of the scaffold concerning the
mechanoregulatory mathematical models of scaffold-assisted cellular differentiation …

Osteoporosis is primarily driven by an imbalance between bone resorption and formation,
stemming from enhanced osteoclast activity during bone remodeling. At the crux of this …

Processing biomaterials into porous scaffolds for bone tissue engineering is a critical and a
key step in defining and controlling their physicochemical, mechanical, and biological …

Bone fractures and critical-size bone defects are significant public health issues, and clinical
treatment outcomes are closely related to the intrinsic properties of the utilized implant …