Therapeutic peptides: current applications and future directions

L Wang, N Wang, W Zhang, X Cheng, Z Yan… - … and Targeted Therapy, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Synthetic biomarkers: a twenty-first century path to early cancer detection

GA Kwong, S Ghosh, L Gamboa, C Patriotis… - Nature Reviews …, 2021 - nature.com
Detection of cancer at an early stage when it is still localized improves patient response to
medical interventions for most cancer types. The success of screening tools such as cervical …

Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

J Li, K Kataoka - Journal of the American Chemical Society, 2020 - ACS Publications
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …

Nanobodies: next generation of cancer diagnostics and therapeutics

EY Yang, K Shah - Frontiers in Oncology, 2020 - frontiersin.org
The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

Engineered nanomedicines with enhanced tumor penetration

J Ding, J Chen, L Gao, Z Jiang, Y Zhang, M Li, Q Xiao… - Nano Today, 2019 - Elsevier
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …

Aptamer functionalized nanomaterials for biomedical applications: Recent advances and new horizons

M Mahmoudpour, S Ding, Z Lyu, G Ebrahimi, D Du… - Nano Today, 2021 - Elsevier
With the advancement of functional nanomaterials and aptamer selection technologies,
aptamer functionalized nanomaterials (AFMs) open various methods to design new sensing …

Applications of surface modification technologies in nanomedicine for deep tumor penetration

Z Li, X Shan, Z Chen, N Gao, W Zeng… - Advanced …, 2021 - Wiley Online Library
The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

E Lagreca, V Onesto, C Di Natale, S La Manna… - Progress in …, 2020 - Springer
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …

Stimulus-responsive polymeric nanogels as smart drug delivery systems

S Hajebi, N Rabiee, M Bagherzadeh, S Ahmadi… - Acta biomaterialia, 2019 - Elsevier
Nanogels are three-dimensional nanoscale networks formed by physically or chemically
cross-linking polymers. Nanogels have been explored as drug delivery systems due to their …