[HTML][HTML] B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. Here, we …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. Here, we …
[HTML][HTML] Epigenetic regulation of B cells and its role in autoimmune pathogenesis
B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …
studies have shown many genetic polymorphisms associated with B-cell activation in …
Memory B cell diversity: insights for optimized vaccine design
The overarching logos of mammalian memory B cells (MBCs) is to cache the potential for
enhanced antibody production upon secondary exposure to cognate antigenic …
enhanced antibody production upon secondary exposure to cognate antigenic …
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood
B cells generate antibodies that are essential for immune protection, but their subgroups are
poorly defined. Here, we perform undirected deep profiling of B cells in matched human …
poorly defined. Here, we perform undirected deep profiling of B cells in matched human …
[HTML][HTML] The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis
Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has
identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T …
identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T …
[HTML][HTML] Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets
Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for
understanding antibody recall upon secondary exposure. Here, we used single-cell …
understanding antibody recall upon secondary exposure. Here, we used single-cell …
[HTML][HTML] Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote liver regeneration via miR-20a-5p/PTEN
J Zhang, J Gao, X Li, D Lin, Z Li, J Wang… - Frontiers in …, 2023 - frontiersin.org
Balancing hepatocyte death and proliferation is key to non-transplantation treatments for
acute liver failure (ALF), which has a high short-term mortality rate. Small extracellular …
acute liver failure (ALF), which has a high short-term mortality rate. Small extracellular …
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Maturation of antibody responses entails somatic hypermutation (SHM), class-switch DNA
recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is …
recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is …
Single-cell RNA sequencing analyses: interference by the genes that encode the B-cell and T-cell receptors
B and T cells are integral parts of the immune system and are implicated in many diseases,
eg autoimmunity. Towards understanding the biology of B and T cells and subsets thereof …
eg autoimmunity. Towards understanding the biology of B and T cells and subsets thereof …
[HTML][HTML] Rad52 mediates class-switch DNA recombination to IgD
In B cells, IgD is expressed together with IgM through alternative splicing of primary VH DJ
HC μ-sm-Cδ-sm RNAs, and also through IgD class switch DNA recombination (CSR) via …
HC μ-sm-Cδ-sm RNAs, and also through IgD class switch DNA recombination (CSR) via …