[HTML][HTML] Sex differences in musculoskeletal injury and disease risks across the lifespan: Are there unique subsets of females at higher risk than males for these …

DA Hart - Frontiers in Physiology, 2023 - frontiersin.org
Sex differences have been reported for diseases of the musculoskeletal system (MSK) as
well as the risk for injuries to tissues of the MSK system. For females, some of these occur …

[HTML][HTML] Quantitative proteomic screening uncovers candidate diagnostic and monitoring serum biomarkers of ankylosing spondylitis

M Hwang, S Assassi, J Zheng, J Castillo… - Arthritis Research & …, 2023 - Springer
Background We sought to discover serum biomarkers of ankylosing spondylitis (AS) for
diagnosis and monitoring disease activity. Methods We studied biologic-treatment-naïve AS …

[HTML][HTML] Development and validation of a machine learning-based nomogram for prediction of ankylosing spondylitis

J Zhu, Q Lu, T Liang, JieJiang, H Li, C Zhou… - Rheumatology and …, 2022 - Springer
Introduction Ankylosing spondylitis (AS) is a chronic progressive inflammatory disease of the
spine and its affiliated tissues. AS mainly affects the axial bone, sacroiliac joint, hip joint …

[HTML][HTML] The Integration of Artificial Intelligence into Clinical Practice

VD Karalis - Applied Biosciences, 2024 - mdpi.com
The purpose of this literature review is to provide a fundamental synopsis of current research
pertaining to artificial intelligence (AI) within the domain of clinical practice. Artificial …

Patients with ankylosing spondylitis present a distinct CD8 T cell subset with osteogenic and cytotoxic potential

V Martini, Y Silvestri, A Ciurea, B Möller, G Danelon… - RMD open, 2024 - rmdopen.bmj.com
Objectives Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease affecting
mainly the axial skeleton. Peripheral involvement (arthritis, enthesitis and dactylitis) and …

Understanding Spondyloarthritis Pathogenesis: The Promise of Single-Cell Profiling

J Ermann, M Lefton, K Wei… - Current Rheumatology …, 2024 - Springer
The use of single-cell profiling approaches in spondyloarthritis research is still in its early
stages. Challenges include high cost and limited availability of diseased tissue samples. To …

[HTML][HTML] Single-Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases

S Jung, JS Lee - Molecules and cells, 2023 - Elsevier
Recent technical advances have enabled unbiased transcriptomic and epigenetic analysis
of each cell, known as “single-cell analysis”. Single-cell analysis has a variety of technical …

Machine learning and deep learning for the diagnosis and treatment of ankylosing spondylitis-a scoping review

S Dhall, A Vaish, R Vaishya - Journal of Clinical Orthopaedics and Trauma, 2024 - Elsevier
Abstract Background and Objectives Machine Learning (ML) and Deep Learning (DL) are
novel technologies that can facilitate early diagnosis of Ankylosing Spondylitis (AS) and …

Single-cell transcriptome revealed dysregulated RNA-binding protein expression patterns and functions in human ankylosing spondylitis

Z Ren, C Li, J Wang, J Sui, Y Ma - Frontiers in Medicine, 2024 - frontiersin.org
Objective To explore the expression characteristics and regulatory patterns of RBPs in
different immune cell types of AS, and to clarify the potential key role of RBPs in the …

[HTML][HTML] Functional genomics implicates natural killer cells as potential key drivers in the pathogenesis of ankylosing spondylitis

M Chiñas, D Fernandez-Salinas, VRC Aguiar… - medRxiv, 2023 - ncbi.nlm.nih.gov
Objective: Multiple lines of evidence indicate that ankylosing spondylitis (AS) is a
lymphocyte-driven disease. However, which lymphocyte populations are critical in AS …