Age-related phenotypic changes of cerebromicrovascular endothelial cells lead to
dysregulation of cerebral blood flow and blood-brain barrier disruption, promoting the …

Aging is associated with increased oxidative stress in vascular endothelial and smooth
muscle cells, which contribute to the development of a wide range of diseases affecting the …

Traumatic brain injury (TBI) results when external physical forces impact the head with
sufficient intensity to cause damage to the brain. TBI can be mild, moderate, or severe and …

The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …

Understanding molecular mechanisms involved in vascular aging is essential to develop
novel interventional strategies for treatment and prevention of age-related vascular …

Aging-induced pathological alterations of the circulatory system play a critical role in
morbidity and mortality of older adults. While the importance of cellular and molecular …

Impaired cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI)
is known to be associated with worse global outcome at 6–12 months. As technology has …

Canine cognitive dysfunction (CCD) is the canine analog of human Alzheimer disease (AD).
CCD is common in older dogs, particularly those more than 8 years old. Slowly progressive …

Age-related alterations in endothelium and the resulting vascular dysfunction critically
contribute to a range of pathological conditions associated with old age. To develop …

There has been an increasing appreciation of the role of vascular contributions to cognitive
impairment and dementia (VCID) associated with old age. Strong preclinical and …