Aging is the most significant risk factor for vascular cognitive impairment (VCI), and the
number of individuals affected by VCI is expected to exponentially increase in the upcoming …

Age-related impairment of neurovascular coupling (NVC;“functional hyperemia”) is a critical
factor in the development of vascular cognitive impairment (VCI). Recent geroscience …

Preclinical studies demonstrate that generalized endothelial cell dysfunction and
microvascular impairment are potentially reversible causes of age-related vascular cognitive …

Hypertension in the elderly substantially increases both the risk of vascular cognitive
impairment (VCI) and Alzheimer's disease (AD); however, the underlying mechanisms are …

Epidemiological studies link long term exposure to xenoestrogen Bisphenol-A to adverse
cardiovascular effects. Our previous results show that BPA induces hypertension by a …

Age-related cerebrovascular pathologies, ranging from cerebromicrovascular functional and
structural alterations to large vessel atherosclerosis, promote the genesis of vascular …

Aging in later life engenders numerous changes to the cerebral microvasculature. Such
changes can remain clinically silent but are associated with greater risk for negative health …

As aging societies in the western world face a growing prevalence of vascular cognitive
impairment and Alzheimer's disease (AD), understanding their underlying causes and …

Age-related cerebrovascular defects contribute to vascular cognitive impairment and
dementia (VCID) as well as other forms of dementia. There has been great interest in …

Aging of the microcirculatory network plays a central role in the pathogenesis of a wide
range of age-related diseases, from heart failure to Alzheimer's disease. In the eye, changes …