Emerging evidence from both clinical and preclinical studies underscores the role of aging
in potentiating the detrimental effects of hypertension on cerebral microhemorrhages …

Background and Purpose—Cerebral microbleeds are linked to cognitive decline, but it
remains unclear how they impair neuronal function. Infarction is not typically observed near …

Clinical studies show that cerebral amyloid angiopathy (CAA) associated with Alzheimer's
disease (AD) and arterial hypertension are independent risk factors for cerebral …

Cognitive impairment is one of the most common co-occurring chronic conditions among
elderly heart failure patients (incidence: up to~ 80%); however, the underlying mechanisms …

Dementia affects almost 50 million adults worldwide, and remains a major cause of death
and disability. Hypertension is a leading risk factor for dementia, including Alzheimer …

Connective tissue growth factor (CTGF, also known as CCN2) is a matricellular protein
expressed in the vascular wall, which regulates diverse cellular functions including cell …

Erythropoietin (EPO), a glycoprotein cytokine essential to hematopoiesis, has
neuroprotective effects in rodent models of Alzheimer's disease (AD). However, high …

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel …

There is correlative evidence that impaired cerebral blood flow (CBF) regulation, in addition
to promoting cognitive impairment, is also associated with alterations in gait and …

Clinical and experimental studies show that age-related decline in circulating insulin-like
growth factor-1 (IGF-1) levels promotes the pathogenesis of intracerebral hemorrhages …