Growing life expectancy will contribute to the on-going shift towards a world population
increasingly comprised of elderly individuals. This demographic shift is associated with a …

Background Cerebral microhemorrhages (CMH) are commonly found in the aging brain.
CMH are also the neuropathological substrate of cerebral microbleeds (CMB), demonstrated …

Two decades into the two thousands, intracerebral hemorrhagic stroke (ICH) continues to
reap lives across the globe. In the US, nearly 12,000 people suffer from ICH every year. Half …

Hypertension is a primary risk factor for the progression of cognitive impairment caused by
cerebral small vessel disease, the most common cerebrovascular disease. However, the …

The recently described perivascular unit (PVU) resides immediately adjacent to the true
capillary neurovascular unit (NVU) in the postcapillary venule and contains the normal …

High salt intake induces hypertension and enhances stroke onset. However, whether an
increase in brain sodium exposure itself is harmful and has poor prognosis remains …

Objective Risk factors and prognosis of cerebral microbleeding (CMB) complicated acute
large artery atherosclerotic cerebral infarction (ALAACI) patients was controversial. Present …

Background and purpose The angiotensin-converting enzyme (ACE) insertion (I)/deletion
(D) polymorphism has been studied as a genetic candidate for cerebral small vessel …

L-methionine, an essential amino acid, plays a critical role in cell physiology. High intake
and/or dysregulation in methionine (Met) metabolism results in accumulation of its …

Hypertensive intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease with
no effective treatment. Lysyl hydroxylase 3 (LH3) is essential for collagen IV intermolecular …