The Catastrophe of Intracerebral Hemorrhage Drives the Capillary-Hemorrhage Dementias, Including Alzheimer's Disease
This review advances an understanding of several dementias, based on four premises. One
is that capillary hemorrhage is prominent in the pathogenesis of the dementias considered …
is that capillary hemorrhage is prominent in the pathogenesis of the dementias considered …
[HTML][HTML] Sex differences in the progression of cerebral microbleeds in patients with concomitant cerebral small vessel disease
CW Yoon, JH Rha, HK Park, SH Park, S Kwon… - Frontiers in …, 2022 - frontiersin.org
Background and purpose Sex differences in cerebral microbleeds (CMBs) are not well-
known. We aimed to assess the impact of sex on the progression of CMBs. Methods The …
known. We aimed to assess the impact of sex on the progression of CMBs. Methods The …
[HTML][HTML] IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
LR Miller, MA Bickel, S Tarantini, ME Runion… - Frontiers in Aging …, 2024 - frontiersin.org
Introduction Cerebrovascular pathologies contribute to cognitive decline during aging,
leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin …
leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin …
The Spectrum of Cerebral Small Vessel Disease: Emerging Pathophysiologic Constructs and Management Strategies
Cerebral small vessel disease (CSVD) results in a spectrum of neurologic, behavioral, and
cognitive sequelae, most commonly from white matter hyperintensities (WMH) of presumed …
cognitive sequelae, most commonly from white matter hyperintensities (WMH) of presumed …
[HTML][HTML] Revealing in vivo cellular mechanisms of cerebral microbleeds on neurons and microglia across cortical layers
Cerebral microbleeds (CMBs) are associated with higher risk for various neurological
diseases including stroke, dementia, and Alzheimer's disease. However, the understanding …
diseases including stroke, dementia, and Alzheimer's disease. However, the understanding …
[HTML][HTML] Evaluating the causal effects of TIMP-3 on ischaemic stroke and intracerebral haemorrhage: a Mendelian randomization study
L Xiao, X Zou, Y Liang, Y Wang, L Zeng, J Wu - Frontiers in Genetics, 2022 - frontiersin.org
Aim: Since tissue inhibitors of matrix metalloproteinase 3 (TIMP-3) was reported to be a
potential risk factor of atherosclerosis, aneurysm, hypertension, and post-ischaemic …
potential risk factor of atherosclerosis, aneurysm, hypertension, and post-ischaemic …
[HTML][HTML] Longitudinal detection of gait alterations associated with hypertension-induced cerebral microhemorrhages in mice: predictive role of stride length and stride …
Cerebral microhemorrhages (CMHs) are of paramount importance as they not only signify
underlying vascular pathology but also have profound implications for cognitive function and …
underlying vascular pathology but also have profound implications for cognitive function and …
[HTML][HTML] Gait variability predicts cognitive impairment in older adults with subclinical cerebral small vessel disease
P Mukli, S Detwiler, CD Owens, T Csipo… - Frontiers in aging …, 2022 - frontiersin.org
Introduction Advanced methods of gait research, including approaches to quantify variability,
and orderliness/regularity/predictability, are increasingly used to identify patients at risk for …
and orderliness/regularity/predictability, are increasingly used to identify patients at risk for …
Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects
LR Miller, MA Bickel, ML Vance, H Vaden, D Nagykaldi… - GeroScience, 2024 - Springer
Cerebrovascular fragility and cerebral microhemorrhages (CMH) contribute to age-related
cognitive impairment, mobility defects, and vascular cognitive impairment and dementia …
cognitive impairment, mobility defects, and vascular cognitive impairment and dementia …
Cerebral Microbleeds Associate with Brain Endothelial Cell Activation-Dysfunction and Blood–Brain Barrier Dysfunction/Disruption with Increased Risk of …
MR Hayden - Biomedicines, 2024 - mdpi.com
Globally, cerebral microbleeds (CMBs) are increasingly being viewed not only as a marker
for cerebral small vessel disease (SVD) but also as having an increased risk for the …
for cerebral small vessel disease (SVD) but also as having an increased risk for the …