The Catastrophe of Intracerebral Hemorrhage Drives the Capillary-Hemorrhage Dementias, Including Alzheimer's Disease

J Stone, J Mitrofanis, DM Johnstone… - Journal of Alzheimer's …, 2024 - content.iospress.com
This review advances an understanding of several dementias, based on four premises. One
is that capillary hemorrhage is prominent in the pathogenesis of the dementias considered …

[HTML][HTML] Sex differences in the progression of cerebral microbleeds in patients with concomitant cerebral small vessel disease

CW Yoon, JH Rha, HK Park, SH Park, S Kwon… - Frontiers in …, 2022 - frontiersin.org
Background and purpose Sex differences in cerebral microbleeds (CMBs) are not well-
known. We aimed to assess the impact of sex on the progression of CMBs. Methods The …

[HTML][HTML] IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice

LR Miller, MA Bickel, S Tarantini, ME Runion… - Frontiers in Aging …, 2024 - frontiersin.org
Introduction Cerebrovascular pathologies contribute to cognitive decline during aging,
leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin …

The Spectrum of Cerebral Small Vessel Disease: Emerging Pathophysiologic Constructs and Management Strategies

RT Muir, EE Smith - Neurologic Clinics, 2024 - neurologic.theclinics.com
Cerebral small vessel disease (CSVD) results in a spectrum of neurologic, behavioral, and
cognitive sequelae, most commonly from white matter hyperintensities (WMH) of presumed …

[HTML][HTML] Revealing in vivo cellular mechanisms of cerebral microbleeds on neurons and microglia across cortical layers

Q Yang, AL Vazquez, XT Cui - Iscience, 2024 - cell.com
Cerebral microbleeds (CMBs) are associated with higher risk for various neurological
diseases including stroke, dementia, and Alzheimer's disease. However, the understanding …

[HTML][HTML] Evaluating the causal effects of TIMP-3 on ischaemic stroke and intracerebral haemorrhage: a Mendelian randomization study

L Xiao, X Zou, Y Liang, Y Wang, L Zeng, J Wu - Frontiers in Genetics, 2022 - frontiersin.org
Aim: Since tissue inhibitors of matrix metalloproteinase 3 (TIMP-3) was reported to be a
potential risk factor of atherosclerosis, aneurysm, hypertension, and post-ischaemic …

[HTML][HTML] Longitudinal detection of gait alterations associated with hypertension-induced cerebral microhemorrhages in mice: predictive role of stride length and stride …

Z Ungvari, M Muranyi, R Gulej, S Negri, A Nyul-Toth… - GeroScience, 2024 - Springer
Cerebral microhemorrhages (CMHs) are of paramount importance as they not only signify
underlying vascular pathology but also have profound implications for cognitive function and …

[HTML][HTML] Gait variability predicts cognitive impairment in older adults with subclinical cerebral small vessel disease

P Mukli, S Detwiler, CD Owens, T Csipo… - Frontiers in aging …, 2022 - frontiersin.org
Introduction Advanced methods of gait research, including approaches to quantify variability,
and orderliness/regularity/predictability, are increasingly used to identify patients at risk for …

Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects

LR Miller, MA Bickel, ML Vance, H Vaden, D Nagykaldi… - GeroScience, 2024 - Springer
Cerebrovascular fragility and cerebral microhemorrhages (CMH) contribute to age-related
cognitive impairment, mobility defects, and vascular cognitive impairment and dementia …

Cerebral Microbleeds Associate with Brain Endothelial Cell Activation-Dysfunction and Blood–Brain Barrier Dysfunction/Disruption with Increased Risk of …

MR Hayden - Biomedicines, 2024 - mdpi.com
Globally, cerebral microbleeds (CMBs) are increasingly being viewed not only as a marker
for cerebral small vessel disease (SVD) but also as having an increased risk for the …