Pharmacotherapy of acute lung injury and acute respiratory distress syndrome

K Raghavendran, GS Pryhuber… - Current medicinal …, 2008 - ingentaconnect.com
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are
characterized by rapid-onset respiratory failure following a variety of direct and indirect …

The clinical practice guideline for the management of ARDS in Japan

S Hashimoto, M Sanui, M Egi, S Ohshimo… - Journal of intensive …, 2017 - Springer
Abstract Background The Japanese Society of Respiratory Care Medicine and the Japanese
Society of Intensive Care Medicine provide here a clinical practice guideline for the …

The β-Agonist Lung Injury Trial (BALTI) a randomized placebo-controlled clinical trial

GD Perkins, DF McAuley, DR Thickett… - American journal of …, 2006 - atsjournals.org
Rationale: Experimental data suggest that manipulation of alveolar fluid clearance with β-
agonists can accelerate the resolution of alveolar edema and improve survival. Objective: To …

Asthma is not only an airway disease, but also a vascular disease

LM Harkness, AW Ashton, JK Burgess - Pharmacology & therapeutics, 2015 - Elsevier
Multiple studies have identified an expansion and morphological dysregulation of the
bronchial vascular network in the airways of asthmatics. Increased number, size and density …

In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury

GD Perkins, F Gao, DR Thickett - Thorax, 2008 - thorax.bmj.com
Background: Acute lung injury is an important cause of respiratory failure in the critically ill
patient. It is caused by damage to the alveolar barrier with subsequent alveolar flooding …

Pharmacologic treatments for acute respiratory distress syndrome

N Qadir, SY Chang - Critical care clinics, 2021 - criticalcare.theclinics.com
Over 50 years have passed since the acute respiratory distress syndrome (ARDS) was first
described. 1 Despite the passage of more than one-half of a century, almost all of ARDS …

Treatment of acute lung injury: current and emerging pharmacological therapies

R Mac Sweeney, M Griffiths… - Seminars in respiratory …, 2013 - thieme-connect.com
As a syndrome of injurious pulmonary inflammation resulting in deranged respiratory
physiology, acute lung injury affords numerous potential therapeutic targets. Two main …

Inhaled β2 adrenergic agonists and other cAMP-elevating agents: therapeutics for alveolar injury and acute respiratory disease syndrome?

K Sriram, MB Insel, PA Insel - Pharmacological Reviews, 2021 - ASPET
Inhaled long-acting β-adrenergic agonists (LABAs) and short-acting β-adrenergic agonists
are approved for the treatment of obstructive lung disease via actions mediated by β 2 …

Bench-to-bedside review: β2-Agonists and the acute respiratory distress syndrome

GD Perkins, DF McAuley, A Richter, DR Thickett, F Gao - Critical Care, 2003 - Springer
The acute respiratory distress syndrome (ARDS) is a devastating constellation of clinical,
radiological and pathological signs characterized by failure of gas exchange and refractory …

[HTML][HTML] Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion …

S Gates, GD Perkins, SE Lamb, C Kelly… - Health technology …, 2013 - ncbi.nlm.nih.gov
BACKGROUND Acute respiratory distress syndrome (ARDS) is a major cause of mortality in
intensive care patients and lacks effective treatments. A previous randomised controlled …