Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

Tanshinones, lipophilic diterpenes isolated from the rhizome of Salvia miltiorrhiza, have
diverse pharmacological activities against human ailments including neurological diseases …

Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the
roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan …

Alzheimer's disease (AD) is the leading cause of dementia in the elderly and is
characterized by progressive cognitive and memory deficits. The pathological hallmarks of …

Zebrafish are now widely accepted as a valuable animal model for a number of different
central nervous system (CNS) diseases. They are suitable both for elucidating the origin of …

Marine and land plastic debris biodegrades at micro-and nanoscales through progressive
fragmentation. Oceanographic model studies confirm the presence of up to∼ 2.41 million …

Seizures are characterized by hypersynchronization of neuronal networks. Understanding
these networks could provide a critical window for therapeutic control of recurrent seizure …

Epilepsy is the most common chronic neurological disease, affecting about 1% of the world's
population during their lifetime. Most people with epilepsy can attain a seizure-free life upon …

In drug discovery, reliable and fast dereplication of known compounds is essential for
identification of novel bioactive compounds. Here, we show an integrated approach using …