Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Drug resistance is a major challenge in cancer treatment. Emerging evidence indicates that
deregulation of YAP/TAZ signaling may be a major mechanism of intrinsic and acquired …

Epigenetic remodeling is essential for oncogene-induced cellular transformation and
malignancy. In contrast to histone post-translational modifications, how DNA methylation is …

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …