Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Simple Summary Metabolic reprogramming is gaining attentions as a hallmark of cancers.
However, lipid metabolism has been difficult to analyze due to technical problems. In recent …

Delivery of nucleic acids, such as mRNA, to immune cells has become a major focus in the
past decade with ionizable lipid nanoparticles (LNPs) emerging as a clinically-validated …

Determining divergent metabolic requirements of T cells, and the viruses and tumours they
fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA: cholesterol …

The neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule in
the brain and in pancreatic islets. Here, we demonstrate that GABA regulates cytokine …

Inflammation represents the driving feature of many diseases, including atherosclerosis,
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …

Immune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies (Abs) and CTLA4 Abs
and T cell-based adoptive cell therapies are effective for patients with various cancers …

CD19-specific CAR-T immunotherapy has been extensively studied for the treatment of B-
cell lymphoma. Recently, cholesterol metabolism has emerged as a modulator of T …

Resistance to drug treatment is a critical barrier in cancer therapy. There is an unmet need to
explore cancer hallmarks that can be targeted to overcome this resistance for therapeutic …

Immuno-oncology not only refers to the multifaceted relationship between our immune
system and a developing cancer but also includes therapeutic approaches that harness the …