Cerebral malaria (CM) is a severe neurological complication of Plasmodium falciparum
infection with acute brain lesions. Genetic variations in both host and parasite have been …

Background According to previous studies, low serum total cholesterol (TC) is associated
with higher cancer incidence and mortality. However, the prognostic implications of …

Advances made in chimeric antigen receptor (CAR) T cell therapy have revolutionized the
treatment and management of certain cancers. Currently, B cell malignancies have been …

胆固醇是生物体内重要的脂质分子， 参与细胞的膜性结构形成、 胆汁酸代谢以及类固醇激素
合成等， 对细胞的结构和功能具有重要的调控作用。 近年来， 大量研究表明胆固醇代谢在肿瘤 …

7-Ketocholesterol (7KCh) is a major oxidized cholesterol product abundant in lipoprotein
deposits and atherosclerotic plaques. Our previous study has shown that 7KCh accumulates …

Low serum cholesterol levels are associated with increased tumor morbidity and mortality.
However, the relationship between serum lipid profile and POEMS syndrome …

Vγ9Vδ2 T cells are immune effector cells very well-suited for immunotherapy, but clinical
results have been disappointing in multiple myeloma (MM) and other cancers. We have …

Repositioning approved antitumor drugs for different cancers is a cost-effective approach.
Gilteritinib was FDA-approved for the treatment of FLT3-mutated acute myeloid leukaemia in …

Identifying metabolic targets that constrain tumours and viruses while boosting exhausted,
dysfunctional T cells can provide novel therapeutic checkpoints. Modulating cholesterol …

Cholesterol, an important lipid molecule of organisms, is involved in the formation of cell
membrane structure, bile acid metabolism and steroid hormone synthesis, playing an …